Yongli Liu,
Xiuping Chi,
Zhe Qiang 
For correspondence:- Zhe Qiang Email: zheqiang20082008@163.com
Accepted: 28 April 2023 Published: 30 May 2023
Citation: Liu Y, Chi X, Qiang Z. Fetal distress and the levels of malondialdehyde (MDA): A meta-analysis. Trop J Pharm Res 2023; 22(5):1109-1114 doi: 10.4314/tjpr.v22i5.25
© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To estimate the effect of malondialdehyde (MDA) level on fetal distress.
Methods: Meta-analyses of randomized controlled interventions were performed by searching 8 electronic databases (CNKI, VIP, CBM, WANFANG, Embase, PubMed, Cochrane, and Web of Science) from 1980 – to date for randomized controlled trials to determine any intrapartum fetal distress. A meta-analysis within a frequentist framework was performed and the quality and inconsistency of the trials were assessed. Dual selection and data abstraction were conducted. The methodological quality of the meta-analyses was assessed using AMSTAR, and the quality of evidence was assessed using GRADE. Random-effect models were used to pool results from individual studies included in each meta-analysis.
Results: A total of 1720 patients received MDA tests, and the results showed that MDA value of experimental group was 1.66 higher than that of control group. Heterogeneity between the two groups was high, suggesting that the choice of blood source significantly affected the result of meta-analysis (p < 0.05). The group of blood samples collected from mothers was highly heterogeneous, and combined with the results of 16 groups, the effective amount reached (2.08) was significant (z = 4.29, p < 0.05). This means that MDA increase in maternal blood during maternal-fetal distress. Secondly, cord blood samples were highly heterogeneous in the collection group, and the random effect was insignificant (z = 0.94, p > 0.05).
Conclusion: Malondialdehyde level in maternal and cord blood reflects the relationship between fetal distress and adverse outcomes. Further research is needed to confirm the extent to which they are related
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